# Semax Research References: Full Citation List with DOIs and PubMed Links > Complete Semax research citation list — 21 peer-reviewed studies with DOIs, PubMed links, and journal details. Indexed from the published literature. ## Semax Research References This page lists all 21 peer-reviewed sources cited across this Semax literature digest. Every citation includes the full bibliographic record, DOI, and PubMed or primary-source URL. [1] Dolotov OV, Karpenko EA, Seredenina TS, et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. Journal of Neurochemistry. 2006. DOI: 10.1111/j.1471-4159.2006.03658.x — https://pubmed.ncbi.nlm.nih.gov/16635254/ [2] Dolotov OV, Karpenko EA, Inozemtseva LS, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research. 2006. DOI: 10.1016/j.brainres.2006.07.108 — https://pubmed.ncbi.nlm.nih.gov/16996037/ [3] Inozemtseva LS, Dolotov OV, Lebedeva OS, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neuroscience Letters. 2006. DOI: 10.1016/j.neulet.2005.11.047 — https://pubmed.ncbi.nlm.nih.gov/16362768/ [4] Sudarkina OY, Filippenkov IB, Stavchansky VV, et al. Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion. International Journal of Molecular Sciences. 2021. DOI: 10.3390/ijms22126179 — https://pubmed.ncbi.nlm.nih.gov/34201112/ [5] Medvedeva EV, Dmitrieva VG, Povarova OV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014. DOI: 10.1186/1471-2164-15-228 — https://pmc.ncbi.nlm.nih.gov/articles/PMC3987924/ [6] Dmitrieva VG, Povarova OV, Skvortsova VI, et al. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell and Molecular Neurobiology. 2010. DOI: 10.1007/s10571-009-9432-0 — https://pubmed.ncbi.nlm.nih.gov/19633950/ [7] Shadrina MI, Dolotov OV, Grivennikov IA, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neuroscience Letters. 2001. DOI: 10.1016/s0304-3940(01)01994-2 — https://pubmed.ncbi.nlm.nih.gov/11457573/ [8] Shadrina M, Kolomin T, Agapova T, et al. Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action. Journal of Molecular Neuroscience. 2010. DOI: 10.1007/s12031-009-9270-z — https://pubmed.ncbi.nlm.nih.gov/19662538/ [9] Shevchenko KV, Nagaev IIu, Alfeeva LIu, et al. Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration. Bioorganicheskaia Khimiia. 2006. DOI: 10.1134/s1068162006010055 — https://pubmed.ncbi.nlm.nih.gov/16523722/ [10] Kost NV, Sokolov OIu, Gabaeva MV, et al. Semax and selank inhibit the enkephalin-degrading enzymes from human serum. Bioorganicheskaia Khimiia. 2001. DOI: 10.1023/a:1011373002885 — https://pubmed.ncbi.nlm.nih.gov/11443939/ [11] Slominsky PA, Shadrina MI, Kolomin TA, et al. Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism. Doklady Biological Sciences. 2017. DOI: 10.1134/S0012496617030048 — https://pubmed.ncbi.nlm.nih.gov/28702721/ [12] Volodina MA, Sebentsova EA, Glazola NYu, et al. Correction of Long-Lasting Negative Effects of Neonatal Isolation in White Rats Using Semax. Acta Naturae. 2012. DOI: PMID 22708068 — https://pmc.ncbi.nlm.nih.gov/articles/PMC3372995/ [13] Volodina MA, Sebentsova EA, Glazova NYu, et al. Semax attenuates the influence of neonatal maternal deprivation on the behavior of adolescent white rats. Bulletin of Experimental Biology and Medicine. 2012. DOI: 10.1007/s10517-012-1574-2 — https://pubmed.ncbi.nlm.nih.gov/22803132/ [14] Grivennikov IA, Dolotov OV, Zolotarev YA, et al. Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons. Restorative Neurology and Neuroscience. 2008. DOI: PMID 18431004 — https://pubmed.ncbi.nlm.nih.gov/18431004/ [15] Kurysheva NI, Shpak AA, Ioileva EE, et al. Semax in the treatment of glaucomatous optic neuropathy in patients with normalized ophthalmic tone. Vestnik Oftalmologii. 2001. — https://pubmed.ncbi.nlm.nih.gov/11569188/ [16] Inozemtseva LS, Yatsenko KA, Glazova NYu, et al. Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress. European Journal of Pharmacology. 2024. DOI: 10.1016/j.ejphar.2024.177068 — https://pubmed.ncbi.nlm.nih.gov/39442746/ [17] Shevchenko KV, Nagaev IYu, Andreeva LA, et al. Study of proteolysis of Semax analogues with different N-terminal amino acids by carboxypeptidases. Doklady Biological Sciences. 2013. DOI: 10.1134/S0012496613030101 — https://pubmed.ncbi.nlm.nih.gov/23821053/ [18] Shevchenko KV, Nagaev IYu, Andreeva LA, et al. Stability of Semax acetyl to proteolysis in various biological media. Doklady Biological Sciences. 2013. DOI: 10.1134/S0012496613020166 — https://pubmed.ncbi.nlm.nih.gov/23652441/ [19] Volodina MA, et al. The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons. Bulletin of Experimental Biology and Medicine. 2025. DOI: 10.1007/s10517-025-06501-z — https://link.springer.com/article/10.1007/s10517-025-06501-z [20] Tomasello MF, Di Rosa MC, Naletova I, et al. Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of Abeta by Metal Ion Stripping and Redox Silencing. Bioinorganic Chemistry and Applications. 2025. DOI: 10.1155/bca/4226220 — https://pmc.ncbi.nlm.nih.gov/articles/PMC12151629/ [21] Liu et al. Semax peptide targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. British Journal of Pharmacology. 2025. DOI: 10.1111/bph.70122 — https://pubmed.ncbi.nlm.nih.gov/40692165/ --- A kiln-fired digest of the peer-reviewed Semax record — heptapeptide research indexed from the literature, no clinic behind the shelf.